Division of Gastroenterology and Hepatology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease and Key Laboratory of Gastroenterology & Hepatology, Ministry of Health Shanghai Jiao-Tong University, Shanghai, People's Republic of China.
PLoS One. 2012;7(7):e39868. doi: 10.1371/journal.pone.0039868. Epub 2012 Jul 31.
We aimed to explore the role of IL-10 -592 A/C SNP in the susceptibility to gastric cancer through a systematic review and meta-analysis. Each initially included article was scored for quality appraisal. 17 studies were eligible for the meta-analysis. We adopted the most probably appropriate genetic model (recessive model). Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated. IL-10-592 AA genotype is associated with the reduced risk of developing gastric cancer among Asians and even apparently observed among Asians high quality subgroup, suggesting IL-10-592 AA genotype may seem to be more protective from overall gastric cancer in Asian populations. IL-10-592 AA genotype is also associated with the overall reduced gastric cancer susceptibility in persons with H. pylori infection compared with controls without H. pylori infection, suggesting IL-10-592 AA genotype may seem to be more protective from overall gastric cancer susceptibility in persons infected with H. pylori. IL-10-592 AA genotype is not associated with either pathologic subtypes (intestinal or diffuse) or anatomic subtypes (non-cardia or cardia) of gastric cancer susceptibility. Genotyping methods like direct sequencing should be highly advocated to be conducted in future well-designed high quality studies among different ethnicities or populations.
我们旨在通过系统评价和荟萃分析探讨 IL-10-592A/C SNP 与胃癌易感性的关系。每个最初纳入的文章都进行了质量评估评分。有 17 项研究符合荟萃分析的条件。我们采用了最可能合适的遗传模型（隐性模型）。通过亚组和敏感性分析寻找潜在的异质性来源，并估计发表偏倚。IL-10-592AA 基因型与亚洲人群患胃癌的风险降低相关，甚至在亚洲高质量亚组中也明显观察到，这表明 IL-10-592AA 基因型似乎对亚洲人群的总体胃癌更具保护作用。与无 H. pylori 感染的对照组相比，IL-10-592AA 基因型与 H. pylori 感染者的总体胃癌易感性降低相关，这表明 IL-10-592AA 基因型似乎对 H. pylori 感染者的总体胃癌易感性更具保护作用。IL-10-592AA 基因型与胃癌的病理亚型（肠型或弥漫型）或解剖亚型（非贲门或贲门）无关。未来应在不同种族或人群中开展设计良好的高质量研究，大力提倡使用直接测序等基因分型方法。
