Dipartimento Farmaco Chimico Tecnologico, Università di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
J Pharm Sci. 2010 Jan;99(1):21-50. doi: 10.1002/jps.21817.
The advent of nanotechnological products in the market, while holding great promise, is raising concerns in consumers. Therefore, this contribution will attempt to compare different particulate formulations and to answer whether their passive penetration into, and potential permeation through the skin may be possible or not. To this end, skin structure, composition, and penetration paths will be concisely reviewed. Parameters generally cited to affect skin absorption will be resumed and commented on from the perspective of potentially penetrating nanosized agents. These sections will provide the basis to understand what is fiction and what is reality.
纳米技术产品进入市场，虽然前景广阔，但也引起了消费者的担忧。因此，本文将尝试比较不同的颗粒制剂，并回答它们是否有可能被动穿透皮肤，以及是否有可能潜在渗透皮肤。为此，本文将简要回顾皮肤结构、组成和渗透途径。本文还将从潜在穿透性纳米制剂的角度，回顾和讨论通常被认为会影响皮肤吸收的参数。这些部分将为理解哪些是虚构的、哪些是现实的提供基础。
