Kakadia Pratibha G, Conway Barbara R
Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Hudders eld HD1 3DH, UK.
Curr Pharm Des. 2015;21(20):2823-9. doi: 10.2174/1381612821666150428143730.
Lipid based drug delivery systems have been widely studied and reported over the past decade and offer a useful alternative to other colloidal drug delivery systems. Skin is a popular route of drug delivery for locally and systemically acting drugs and nanoparticles are reported as a potential formulation strategy for dermal delivery. Although the skin acts as a natural physical barrier against penetration of foreign materials, including particulates, opportunities exist for the delivery of therapeutic nanoparticles, especially in diseased and damaged skin and via appendageal routes such as the openings of hair follicles. The extent and ability of nanoparticles to penetrate into the underlying viable tissue is still the subject of debate although recent studies have identified the follicular route as the most likely route of entry; this influences the potential applications of these dosage forms as a drug delivery strategy. This paper reviews present state of art of lipid-based nanocarriers focussing on solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsions, their production methods, potential advantages and applications in dermal drug delivery.
在过去十年中，基于脂质的药物递送系统得到了广泛研究和报道，为其他胶体药物递送系统提供了一种有用的替代方案。皮肤是局部和全身作用药物常用的给药途径，纳米颗粒被报道为一种潜在的皮肤给药制剂策略。尽管皮肤作为一种天然的物理屏障，可防止包括颗粒物质在内的外来物质渗透，但治疗性纳米颗粒的给药仍存在机会，特别是在患病和受损皮肤中，以及通过毛囊开口等附属途径。尽管最近的研究已确定毛囊途径是最可能的进入途径，但纳米颗粒渗透到下层活组织中的程度和能力仍是一个有争议的问题；这影响了这些剂型作为药物递送策略的潜在应用。本文综述了基于脂质的纳米载体的研究现状，重点关注固体脂质纳米粒、纳米结构脂质载体和纳米乳剂，它们的制备方法、潜在优势以及在皮肤药物递送中的应用。
