Tamiolakis D, Barbagadaki S, Proimos E, Nikolaidou S, Chimona T S, Georgiou G, Perogamvrakis G, Papadakis C E
Department of Cytopathology, General Hospital of Chania, Crete, Greece.
B-ENT. 2009;5(2):115-8.
Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis. Langerhans cell histiocytosis (LCH) is a rare neoplasm of the mononuclear phagocytic immunoregulatory system of unknown aetiology. Nodal involvement is uncommon. Cytological findings have seldom been described. A case study of LCH, arising in a submandibular node of a 42-year-old female, is reported. Fine needle aspiration smears were highly cellular and composed of a mixed cell population including eosinophils, lymphocytes, neutrophils, and macrophages. Imprint slides from the surgical specimen of the excised node exhibited Langerhans cells with nuclear grooves, leading to a diagnosis suggestive of LCH. Immunohistochemical staining of the node sections with CD1a and S-100 confirmed this diagnosis. In conclusion, cytology may favorably contribute to the diagnosis of LCH.
淋巴结朗格汉斯细胞组织细胞增多症的触摸印片细胞学诊断。朗格汉斯细胞组织细胞增多症（LCH）是一种病因不明的罕见的单核吞噬细胞免疫调节系统肿瘤。淋巴结受累并不常见。细胞学表现很少被描述。本文报道了一例发生于一名42岁女性下颌下淋巴结的LCH病例。细针穿刺涂片细胞丰富，由包括嗜酸性粒细胞、淋巴细胞、中性粒细胞和巨噬细胞在内的混合细胞群组成。切除淋巴结手术标本的印片显示有核沟的朗格汉斯细胞，提示诊断为LCH。用CD1a和S-100对淋巴结切片进行免疫组化染色证实了这一诊断。总之，细胞学检查可能有助于LCH的诊断。
