Kirchgraber P R, Weaver M G, Arafah B M, Abdul-Karim F W
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Acta Cytol. 1994 Jan-Feb;38(1):101-6.
We present an unusual case of Langerhans cell histiocytosis (LCH) involving the thyroid gland initially diagnosed by fine needle aspiration biopsy in a 16-year-old boy. The cytologic findings in LCH involving the thyroid include high cellularity, isolated Langerhans cells with prominent nuclear grooves, multinucleate Langerhans cells, eosinophils, lymphocytes and rare benign follicular cells. Confirmation of LCH was obtained by core biopsy, positive S-100 protein immunohistochemical staining and the demonstration of Birbeck granules on electron microscopy. We present the complete clinicopathologic features of this case with a review of the literature and discussion of the differential diagnosis.
我们报告一例罕见的朗格汉斯细胞组织细胞增多症（LCH）累及甲状腺的病例，该病例最初由细针穿刺活检诊断，患者为一名16岁男孩。累及甲状腺的LCH的细胞学表现包括细胞丰富、孤立的具有明显核沟的朗格汉斯细胞、多核朗格汉斯细胞、嗜酸性粒细胞、淋巴细胞以及罕见的良性滤泡细胞。通过芯针活检、S-100蛋白免疫组化染色阳性以及电镜下发现Birbeck颗粒确诊为LCH。我们展示了该病例完整的临床病理特征，并对文献进行了回顾以及对鉴别诊断进行了讨论。
