Jarstrand C, Holmquist L, Wiernik A, Akerlund B, Carlson L A
Department of Microbiology, Huddinge University Hospital, Stockholm, Sweden.
J Clin Lab Immunol. 1990 Oct;33(2):69-73.
High Density Lipoproteins (HDL) from three patients with E. coli sepsis contained high, low and no Serum Amyloid Protein (Apo SAA), respectively. Preincubation of neutrophils from healthy persons for half an hour with sepsis HDL as well as normal HDL increased the phagocytosis, the stimulated nitroblue tetrazolium reduction, the chemotaxis and the random migrations of these cells. However, for all these functions, lower values were obtained after incubation with sepsis HDL containing high amounts of apo SAA than with normal HDL. A qualitative change of HDL might thus in part be responsible for the decreased function of neutrophils noted during the acute phase of bacterial infections.
三名大肠杆菌败血症患者的高密度脂蛋白（HDL）分别含有高、低和无血清淀粉样蛋白（载脂蛋白SAA）。将健康人的中性粒细胞与败血症HDL以及正常HDL预孵育半小时，可增加这些细胞的吞噬作用、刺激的硝基蓝四氮唑还原、趋化性和随机迁移。然而，对于所有这些功能，与含有大量载脂蛋白SAA的败血症HDL孵育后获得的值低于与正常HDL孵育后的值。因此，HDL的定性变化可能部分导致细菌感染急性期中性粒细胞功能下降。
