Gul'neva M Iu, Shilkina N P
Klin Med (Mosk). 2009;87(6):42-5.
This study of intestinal microflora included 60 patients with systemic lupus erythematosus (LE) and 30 ones with cardiologic problems (controls). LE was diagnosed using criteria of American Rheumatologic Association (1982). Activity of the disease was estimated based on the ECLAM index. Nineteen patients with grade II LE were given with prednisolone (15 mg/day) and 15 ones did not receive this treatment. The qualitative and quantitative composition of intestinal microflora was evaluated by bacteriological methods. Results of the study were analysed with the use of STATISTICA 6.0 software system (StatSoft). Prednisolone was shown to alter the qualitative composition of microflora and the structure of symbiotic interactions between different organisms. Specifically, colonic flora contained more enterococci and organisms possessed of hemolytic activity whereas quantitative composition remained practically unchanged. Enterococci and colibacilli with modified enzymatic activity became predominant forms. It is concluded that prednisolone therapy affects colonic microbiocenosis in patients with LE favouring the development of enterococci, atypical colibacilli, and organisms with hemolytic activity.
这项关于肠道微生物群的研究纳入了60例系统性红斑狼疮（LE）患者和30例有心脏问题的患者（对照组）。LE依据美国风湿病学会（1982年）的标准进行诊断。根据欧洲抗风湿病联盟（EULAR）活动指数评估疾病活动度。19例II级LE患者接受了泼尼松龙治疗（15毫克/天），15例未接受该治疗。通过细菌学方法评估肠道微生物群的定性和定量组成。使用STATISTICA 6.0软件系统（StatSoft）对研究结果进行分析。结果显示，泼尼松龙会改变微生物群的定性组成以及不同生物体之间共生相互作用的结构。具体而言，结肠菌群中肠球菌和具有溶血活性的生物体增多，而定量组成基本保持不变。具有改变的酶活性的肠球菌和大肠杆菌成为主要形式。结论是，泼尼松龙治疗会影响LE患者的结肠微生物群落，有利于肠球菌、非典型大肠杆菌和具有溶血活性的生物体的生长。
