Gul'neva M Iu, Noskov S M
Klin Med (Mosk). 2011;89(4):45-8.
The aim of the work was to study colonic microbial biocenosis and colonizing ability of opportunistic bacteria in 32 patients with rheumatoid arthritis (RA) and 30 healthy subjects. RA was diagnosed based on the American Rheumatism Association criteria (1987). Qualitative and quantitative composition of the microflora was detected by a bacteriological method. StatSoft Statistics 6.0 was used to treat the data obtained. RA was associated with significant modification of the intestinal flora, viz. decrease in lactobacteria and significant increase of enterococci, clostridia, colibacteria showing reduced enzymatic activity, and opportunistic species. Also, symbiotic relationships between microorganisms altered. The fraction of bifidobacteria, bacteroids, and lactopositive colibacteria reduced while the abundance of opportunistic enterobacteria and staphylococci was elevated. Opportunistic Enterobacteriaceae were present in urine and nasal mucosa which suggested their translocation from the intestines. It is concluded that changes in intestinal microflora and colonization by opportunistic bacteria enhance the risk of development of co-morbid conditions in patients with RA.
这项研究的目的是研究32例类风湿关节炎（RA）患者和30名健康受试者的结肠微生物群落及机会致病菌的定植能力。RA的诊断依据美国风湿病协会标准（1987年）。采用细菌学方法检测微生物群落的定性和定量组成。使用StatSoft Statistics 6.0软件处理所获得的数据。RA与肠道菌群的显著改变有关，即乳酸菌数量减少，肠球菌、梭菌、酶活性降低的大肠杆菌及机会致病菌数量显著增加。此外，微生物之间的共生关系也发生了改变。双歧杆菌、拟杆菌和乳糖阳性大肠杆菌的比例降低，而机会性肠杆菌和葡萄球菌的数量增加。尿液和鼻粘膜中存在机会性肠杆菌科细菌，这表明它们从肠道发生了移位。得出的结论是，肠道微生物群的变化和机会致病菌的定植增加了RA患者发生合并症的风险。
