Crimmins Michael T, Stevens Jason M, Schaaf Gregory M
Kenan and Caudill Laboratories of Chemistry, University of North Carolina at Chapel Hill, North Carolina 27599, USA.
Org Lett. 2009 Sep 3;11(17):3990-3. doi: 10.1021/ol901655e.
The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis.
据报道,(+)-iriciniastatin A(苔藓抑素)的全合成以19步完成,总产率为6%。关键反应包括高度汇聚的烯醇硅烷-氧鎓离子结合以生成C8-C25片段,以及半缩醛胺与酰氯的后期偶联以完成合成。