Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA.
J Am Chem Soc. 2011 Jun 29;133(25):9727-9. doi: 10.1021/ja204228q. Epub 2011 Jun 8.
The synthesis of the potent molluscicide cyanolide A has been achieved in 10 steps without the use of protecting groups. The synthesis features a key Sakurai macrocyclization/dimerization reaction that simultaneously forms both tetrahydropyran rings and the macrocycle of the natural product.
强力杀螺剂氰醇 A 的合成已经实现，共 10 步，不使用保护基团。该合成的关键步骤是 Sakurai 大环化/二聚反应，同时形成四氢吡喃环和天然产物的大环。
