Vechorkin Oleg, Barmaz Delphine, Proust Valérie, Hu Xile
Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, SB-ISIC-LSCI, BCH 3305, Lausanne CH 1015, Switzerland.
J Am Chem Soc. 2009 Sep 2;131(34):12078-9. doi: 10.1021/ja906040t.
Ni-catalyzed Sonogashira coupling of nonactivated, beta-H-containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl halide, in both coupling partners. The coupling can be selective for a specific C-X bond (X = I, Br, Cl) and allows for orthogonal functionalization of alkyl halides with multiple reactive sites.
据报道，镍催化未活化的含β-氢烷基卤化物（包括氯化物）的Sonogashira偶联反应。该偶联反应对两种偶联底物中广泛的官能团具有耐受性，包括醚、酯、酰胺、腈、酮、杂环、缩醛和芳基卤化物。该偶联反应可以对特定的C-X键（X = I、Br、Cl）具有选择性，并允许对具有多个反应位点的烷基卤化物进行正交官能化。
