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Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens.

作者信息

Berger P, Elsworth J D, Arroyo J, Roth R H

机构信息

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.

出版信息

Eur J Pharmacol. 1990 Feb 20;177(1-2):91-4. doi: 10.1016/0014-2999(90)90554-j.

DOI:10.1016/0014-2999(90)90554-j
PMID:1967129
Abstract

Although some behavioral effects of cocaine are hypothesized to be due to blockade of dopamine uptake in nucleus accumbens, it has been reported that in nucleus accumbens there are no specific cocaine binding sites and that cocaine is a weak inhibitor of dopamine uptake. [3H]GBR 12935 and an unlabelled analog, GBR 12909, are ligands that bind with great affinity and specificity to a site on dopamine uptake complex in striatum. We therefore investigated the interaction of these GBR compounds with the dopamine uptake complex in nucleus accumbens. We found specific high affinity [3H]GBR 12935 binding and a significant correlation between displacement of [3H]GBR 12935 binding by a series of compounds in striatum and nucleus accumbens. GBR 12909 inhibited dopamine uptake with equal potency in nucleus accumbens and striatum. Thus, there appear to be some aspects of the dopamine uptake complex in nucleus accumbens and striatum that are similar.

摘要

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