Missale C, Castelletti L, Govoni S, Spano P F, Trabucchi M, Hanbauer I
J Neurochem. 1985 Jul;45(1):51-6. doi: 10.1111/j.1471-4159.1985.tb05473.x.
Active uptake of 3,4-dihydroxyphenylethylamine (dopamine) is sodium- and temperature-dependent, strongly inhibited by benztropine and nomifensine, and present in corpus striatum and nucleus accumbens. In rat striatum dopamine uptake is related to a receptor that is specifically labelled by [3H]cocaine in the presence of Na+ and is located on dopaminergic terminals. The dopamine uptake is differentially affected in the two areas by single or repeated injections of cocaine. Cocaine inhibits dopamine uptake in slices of corpus striatum. Moreover Na+-dependent [3H]cocaine binding is not detectable in nucleus accumbens. Nomifensine inhibits [3H]dopamine uptake by interacting with low- and high-affinity sites in corpus striatum, but shows only low affinity for dopamine uptake in nucleus accumbens. The present data indicate that different mechanisms are involved in the regulation of dopamine uptake in corpus striatum and nucleus accumbens.
3,4-二羟基苯乙胺（多巴胺）的主动摄取依赖于钠和温度，受苯海索和诺米芬辛强烈抑制，且存在于纹状体和伏隔核中。在大鼠纹状体中，多巴胺摄取与一种受体相关，该受体在存在Na+的情况下可被[3H]可卡因特异性标记，且位于多巴胺能终末上。单次或重复注射可卡因对这两个区域的多巴胺摄取有不同影响。可卡因抑制纹状体切片中的多巴胺摄取。此外，在伏隔核中检测不到依赖Na+的[3H]可卡因结合。诺米芬辛通过与纹状体中的低亲和力和高亲和力位点相互作用来抑制[3H]多巴胺摄取，但对伏隔核中的多巴胺摄取仅表现出低亲和力。目前的数据表明，纹状体和伏隔核中多巴胺摄取的调节涉及不同机制。
