Yildirim Fatma Elif, Karaduman Ayşen, Hürmüz Pervin, Ozyar Enis, Barişta Ibrahim, Sağlam Arzu
Department of Dermatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
J Cutan Pathol. 2010 May;37(5):600-4. doi: 10.1111/j.1600-0560.2009.01393.x. Epub 2009 Aug 5.
Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is an indolent low grade B cell lymphoma of the skin, with lack of extracutaneous involvement at the time of diagnosis. Herein we report the case of a patient with rheumatoid arthritis (RA) who developed symmetrical PCMZL lesions on both ear lobes. Lesions occurring symmetrically on ear lobes are more specific for cutaneous lymphoid hyperplasia (CLH) and this kind of symmetrical localization hasn't been reported for PCMZL before. PCMZL is considered to arise from a background of reactive lymphoid hyperplasia and this case point out the concept of CLH and PCMZL spectrum. Association of marginal zone lymphoma with rheumatoid arthritis and resolution of lesions together with the resolution of symptoms due to rheumatoid arthritis after rituximab therapy is another interesting point for this case. To the best of our knowledge PCMZL associated with RA has not been reported previously.
原发性皮肤边缘区B细胞淋巴瘤（PCMZL）是一种皮肤的惰性低度B细胞淋巴瘤，诊断时无皮肤外受累。在此我们报告1例类风湿关节炎（RA）患者，其双耳耳垂出现对称性PCMZL病变。耳垂对称性出现的病变对皮肤淋巴组织增生（CLH）更具特异性，且此前尚未有PCMZL这种对称分布的报道。PCMZL被认为起源于反应性淋巴组织增生背景，该病例指出了CLH与PCMZL谱系的概念。边缘区淋巴瘤与类风湿关节炎的关联以及病变随利妥昔单抗治疗后类风湿关节炎症状的缓解而消退是该病例的另一个有趣之处。据我们所知，此前尚未报道过与RA相关的PCMZL。
