甘油磷酸胆碱渗透调节的新进展是什么？
What's new about osmotic regulation of glycerophosphocholine.
作者信息
Gallazzini Morgan, Burg Maurice B
机构信息
Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Physiology (Bethesda). 2009 Aug;24:245-9. doi: 10.1152/physiol.00009.2009.
Abstract
Glycerophosphocholine is an abundant renal medullary organic osmolyte that protects renal medullary cells from the high interstitial concentrations of NaCl and urea to which they are normally exposed. We consider the metabolism of glycerophosphocholine, its osmotic regulation, and the recently discovered molecular identity of the enzymes that osmoregulate its abundance.
摘要
甘油磷酸胆碱是一种丰富的肾髓质有机渗透溶质，可保护肾髓质细胞免受它们通常所暴露的高浓度间质氯化钠和尿素的影响。我们将探讨甘油磷酸胆碱的代谢、其渗透调节以及最近发现的对其丰度进行渗透调节的酶的分子特性。
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本文引用的文献
1
GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC.GDPD5是一种甘油磷酸胆碱磷酸二酯酶，可通过渗透作用调节具有渗透保护作用的有机渗透物GPC。
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11026-31. doi: 10.1073/pnas.0805496105. Epub 2008 Jul 30.
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