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[使用健康保险数据库对具有回顾期的合并症测量进行的比较研究:以接受经皮冠状动脉介入治疗的患者为重点]

[A comparative study on comorbidity measurements with Lookback period using health insurance database: focused on patients who underwent percutaneous coronary intervention].

作者信息

Kim Kyoung Hoon, Ahn Lee Su

机构信息

Review & Assessment Policy Institute, Health Insurance Review & Assessment Service, Korea.

出版信息

J Prev Med Public Health. 2009 Jul;42(4):267-73. doi: 10.3961/jpmph.2009.42.4.267.

Abstract

OBJECTIVES

To compare the performance of three comorbidity measurements (Charlson comorbidity index, Elixhauser's comorbidity and comorbidity selection) with the effect of different comorbidity lookback periods when predicting in-hospital mortality for patients who underwent percutaneous coronary intervention.

METHODS

This was a retrospective study on patients aged 40 years and older who underwent percutaneous coronary intervention. To distinguish comorbidity from complications, the records of diagnosis were drawn from the National Health Insurance Database excluding diagnosis that admitted to the hospital. C-statistic values were used as measures for in comparing the predictability of comorbidity measures with lookback period, and a bootstrapping procedure with 1,000 replications was done to determine approximate 95% confidence interval.

RESULTS

Of the 61,815 patients included in this study, the mean age was 63.3 years (standard deviation: +/-10.2) and 64.8% of the population was male. Among them, 1,598 (2.6%) had died in hospital. While the predictive ability of the Elixhauser s comorbidity and comorbidity selection was better than that of the Charlson comorbidity index, there was no significant difference among the three comorbidity measurements. Although the prevalence of comorbidity increased in 3 years of lookback periods, there was no significant improvement compared to 1 year of a lookback period.

CONCLUSIONS

In a health outcome study for patients who underwent percutaneous coronary intervention using National Health Insurance Database, the Charlson comorbidity index was easy to apply without significant difference in predictability compared to the other methods. The one year of observation period was adequate to adjust the comorbidity. Further work to select adequate comorbidity measurements and lookback periods on other diseases and procedures are needed.

摘要

目的

比较三种合并症测量方法(查尔森合并症指数、埃利克斯豪泽合并症指数和合并症选择法)在预测接受经皮冠状动脉介入治疗患者的院内死亡率时,不同合并症回顾期所产生的影响。

方法

这是一项针对40岁及以上接受经皮冠状动脉介入治疗患者的回顾性研究。为了区分合并症与并发症,诊断记录取自国民健康保险数据库,排除入院时的诊断。C统计值用于比较合并症测量方法在不同回顾期的预测能力,并采用1000次重复抽样程序来确定近似的95%置信区间。

结果

本研究纳入的61815例患者中,平均年龄为63.3岁(标准差:±10.2)男性占64.8%。其中,1598例(2.6%)在医院死亡。虽然埃利克斯豪泽合并症指数和合并症选择法的预测能力优于查尔森合并症指数,但三种合并症测量方法之间无显著差异。尽管在3年回顾期内合并症患病率有所增加,但与1年回顾期相比,并无显著改善。

结论

在一项利用国民健康保险数据库对接受经皮冠状动脉介入治疗患者进行的健康结局研究中,查尔森合并症指数易于应用,与其他方法相比,预测性无显著差异。1年的观察期足以调整合并症情况。还需要进一步开展工作,以选择适用于其他疾病和治疗程序的合并症测量方法及回顾期。

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