Tamura Gen, Sakae Hirokazu, Fujino Satoshi
Airway Institute in Sendai Co., Ltd.
Arerugi. 2009 Jul;58(7):790-7.
To evaluate the performances of various devices for inhaled steroid.
Aerosol particle diameters were determined using the Aerodynamic Particle Sizer Spectrometer. Conversion ratios to fine particle aerosol were determined using an Andersen non-bubble sampler.
The mass median aerodynamic diameter was between 1 and 4 microm for all devices examined, tending to decrease with the increase in a suction flow rate. The percent of drug aerosolized less than 11 microm in diameter at a suction flow rate of 28.3 L/min was 100% for BDP-HFA and CIC-HFA, 87.5% for FP-HFA, 47.0% for BUD-DPI, 6.2% for FP-DPI, and 4.9% for SFC-DPI. The percent of drug aerosolized less than 7.6 microm in diameter at a suction flow rate of 60 L/min was 78.2% for BUD-DPI, 5.9% for FP-DPI, and 6.5% for SFC-DPI.
For MDI preparations, devices permitting easy synchronization of drug atomization and inspiration exhibited higher inhalation efficiency. For DPI preparations, the BUD-DPI device exhibited higher inhalation efficiency, which was enhanced by increasing the suction flow rate.
评估各种吸入性类固醇装置的性能。
使用空气动力学粒径分析仪测定气溶胶粒径。使用安德森无泡采样器测定细颗粒气溶胶的转换率。
所有受试装置的质量中值空气动力学直径在1至4微米之间，且随吸气流量增加有减小趋势。在28.3升/分钟的吸气流量下，直径小于11微米的药物气溶胶百分比，布地奈德-氢氟烷烃（BDP-HFA）和环索奈德-氢氟烷烃（CIC-HFA）为100%，氟替卡松-氢氟烷烃（FP-HFA）为87.5%，布地奈德干粉吸入剂（BUD-DPI）为47.0%，氟替卡松干粉吸入剂（FP-DPI）为6.2%，司力可干粉吸入剂（SFC-DPI）为4.9%。在60升/分钟的吸气流量下，直径小于7.6微米的药物气溶胶百分比，布地奈德干粉吸入剂为78.2%，氟替卡松干粉吸入剂为5.9%，司力可干粉吸入剂为6.5%。
对于定量吸入气雾剂（MDI）制剂，能使药物雾化与吸气轻松同步的装置具有更高的吸入效率。对于干粉吸入剂（DPI）制剂，布地奈德干粉吸入剂装置具有更高的吸入效率，且通过增加吸气流量可提高该效率。
