Duvivier D H, Chiap P, Crommen J, Lekeux P
Laboratoire d'investigation fonctionnelle, Faculté de médecine vétérinaire, Université de Liège, Sart Tilman, Belgium.
Vet Res. 1997 Nov-Dec;28(6):557-64.
The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M). The in vitro inhalation study was performed using the cascade impaction method (Andersen Sampler) adapted to imitate nasal breathing. The amount of ipratropium found in the device, the artificial upper airways and the six stages of the Andersen Sampler was measured using high precision liquid chromatography. Stage 1 of the Andersen Sampler was considered to be the respirable fraction and stages 2 to 6 to be the non-respirable fraction. It was concluded that the theoretical respirable fraction of ipratropium obtained after DPI through Inhalator M was influenced by relative air humidity, air flow and the position of the device, whereas the number of successive inspirations and the duration of inspiration did not affect this fraction of the drug.
本研究的目的是确定呼吸模式、空气湿度和装置位置对干粉吸入（DPI）装置（吸入器M）产生的气雾剂递送的影响。体外吸入研究采用改良的级联撞击法（安德森采样器）来模拟鼻腔呼吸。使用高精度液相色谱法测量装置、人工上呼吸道和安德森采样器六个阶段中异丙托溴铵的含量。安德森采样器的第1阶段被视为可吸入部分，第2至6阶段被视为不可吸入部分。得出的结论是，通过吸入器M进行DPI后获得的异丙托溴铵理论可吸入部分受相对空气湿度、气流和装置位置的影响，而连续吸气次数和吸气持续时间对该药物的这一部分没有影响。
