Lill Roland
Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, D-35033 Marburg, Germany.
Nature. 2009 Aug 13;460(7257):831-8. doi: 10.1038/nature08301.
Iron-sulphur (Fe-S) clusters have long been recognized as essential and versatile cofactors of proteins involved in catalysis, electron transport and sensing of ambient conditions. Despite the relative simplicity of Fe-S clusters in terms of structure and composition, their synthesis and assembly into apoproteins is a highly complex and coordinated process in living cells. Different biogenesis machineries in both bacteria and eukaryotes have been discovered that assist Fe-S-protein maturation according to uniform biosynthetic principles. The importance of Fe-S proteins for life is documented by an increasing number of diseases linked to these components and their biogenesis.
铁硫（Fe-S）簇长期以来一直被认为是参与催化、电子传递和环境条件传感的蛋白质的重要且多功能的辅因子。尽管Fe-S簇在结构和组成方面相对简单，但其合成以及组装到脱辅基蛋白中是活细胞中一个高度复杂且协调的过程。在细菌和真核生物中都发现了不同的生物合成机制，它们根据统一的生物合成原理协助Fe-S蛋白成熟。越来越多与这些成分及其生物合成相关的疾病证明了Fe-S蛋白对生命的重要性。
