Department of Pharmacy, Faculty of Health Sciences, Oslo University College, Pilestredet 50, N-0167 Oslo, Norway.
Epilepsy Res. 2009 Nov;87(1):31-9. doi: 10.1016/j.eplepsyres.2009.07.005. Epub 2009 Aug 13.
The aim of the study was to quantify the use of antiepileptic drugs (AEDs) in epilepsy and other indications in a nation-wide population using a prescription database.
Prescription data of AEDs were collected from the Norwegian Prescription Database for the period 2004-2007, including 5.1 million prescriptions from 144,653 patients, all having at least one prescribed and dispensed AED. Diagnosis-related reimbursement codes were used as indicators for clinical use.
Of the AEDs used, 71% was in epilepsy, 15% in psychiatry, 13% in neuropathic pain, and <1% in migraine, trigeminus neuralgia and cancer adjuvance. The use in epilepsy increased steadily from 7.0 to 7.5 DDDs/1000 inhabitants/day (7%) from 2004 to 2007. The use of AEDs in other indications increased considerably more from 2004 to 2007: Neuropathic pain to 1.40 DDDs/1000 inhabitants/day (360%), psychiatry to 1.59 (200%), and migraine to 0.005 (642%). The prevalence of AED users increased and in 2007 it was 0.97% in epilepsy, 0.8% in neuropathic pain, 0.33% in psychiatry and 0.001% in migraine. In 2007, 49% of the AEDs used in epilepsy were a new drug, carbamazepine, lamotrigine and valproate being most frequently used. New AEDs were used in 96% in migraine prophylaxis, 94% in neuropathic pain, and 64% in psychiatry.
Based on a nation-wide prescription database, this study quantifies the wide and increasing use of AEDs, in particular the newer drugs.
本研究旨在通过处方数据库，量化全国范围内抗癫痫药（AEDs）在癫痫和其他适应证中的使用情况。
2004-2007 年期间，从挪威处方数据库中收集了 AED 的处方数据，包括 144653 名患者的 510 万张处方，所有患者均至少有一张处方和配药的 AED。诊断相关的报销代码被用作临床使用的指标。
在所使用的 AED 中，71%用于癫痫，15%用于精神科，13%用于神经病理性疼痛，<1%用于偏头痛、三叉神经痛和癌症辅助治疗。2004 年至 2007 年，癫痫患者的 AED 使用量从 7.0 增至 7.5 DDD/1000 居民/天（7%），呈稳步上升趋势。2004 年至 2007 年，其他适应证的 AED 使用量大幅增加：神经病理性疼痛增至 1.40 DDD/1000 居民/天（360%）、精神科增至 1.59（200%）、偏头痛增至 0.005（642%）。AED 使用者的患病率增加，2007 年癫痫为 0.97%，神经病理性疼痛为 0.8%，精神科为 0.33%，偏头痛为 0.001%。2007 年，癫痫中使用的 AED 有 49%为新药，其中卡马西平、拉莫三嗪和丙戊酸钠的使用最为频繁。偏头痛预防中使用了 96%的新型 AED，神经病理性疼痛中使用了 94%，精神科中使用了 64%。
基于全国范围内的处方数据库，本研究量化了 AED 的广泛且不断增加的使用情况，特别是新型药物。
