Sopko Richelle, McNeill Helen
Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Department of Molecular Genetics, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada.
Curr Opin Cell Biol. 2009 Oct;21(5):717-23. doi: 10.1016/j.ceb.2009.07.001. Epub 2009 Aug 11.
Fat is an extremely large atypical cadherin involved in the regulation of cell adhesion, tissue growth, and planar cell polarity (PCP). Recent studies have begun to illuminate the mechanisms by which Fat performs these functions during development. Fat relays signals to the Hippo pathway to regulate tissue growth, and to PCP proteins to regulate tissue patterning. In this review we briefly cover the historical data demonstrating that Fat regulates tissue growth and tissue patterning, and then focus on advances in the past three years illuminating the mechanisms by which Fat controls growth and planar polarity in flies and mammals.
Fat是一种极大的非典型钙黏着蛋白，参与细胞黏附、组织生长和平面细胞极性（PCP）的调控。最近的研究已开始阐明Fat在发育过程中执行这些功能的机制。Fat将信号传递给Hippo通路以调节组织生长，并传递给PCP蛋白以调节组织模式形成。在本综述中，我们简要介绍了表明Fat调节组织生长和组织模式形成的历史数据，然后重点关注过去三年中有关Fat在果蝇和哺乳动物中控制生长及平面极性机制的研究进展。
