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Hippo 信号通路及其在人类健康和疾病中的意义。

The Hippo signalling pathway and its implications in human health and diseases.

机构信息

Breast Disease Center, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, South of Renmin Road, 610041, Chengdu, China.

Department of Pediatric Nephrology Nursing, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, 610041, Chengdu, China.

出版信息

Signal Transduct Target Ther. 2022 Nov 8;7(1):376. doi: 10.1038/s41392-022-01191-9.

DOI:10.1038/s41392-022-01191-9
PMID:36347846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9643504/
Abstract

As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in the regulation of numerous biological processes. Thus, substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway, as well as its physiological functions, such as cell proliferation and differentiation, organ growth, embryogenesis, and tissue regeneration/wound healing. However, dysregulation of the Hippo pathway can cause a variety of diseases, including cancer, eye diseases, cardiac diseases, pulmonary diseases, renal diseases, hepatic diseases, and immune dysfunction. Therefore, therapeutic strategies that target dysregulated Hippo components might be promising approaches for the treatment of a wide spectrum of diseases. Here, we review the key components and upstream signals of the Hippo pathway, as well as the critical physiological functions controlled by the Hippo pathway. Additionally, diseases associated with alterations in the Hippo pathway and potential therapies targeting Hippo components will be discussed.

摘要

作为一个进化上保守的信号网络，Hippo 通路在调节许多生物过程中起着至关重要的作用。因此，人们做出了巨大的努力来理解影响 Hippo 通路活性的上游信号及其生理功能，如细胞增殖和分化、器官生长、胚胎发生和组织再生/伤口愈合。然而，Hippo 通路的失调会导致多种疾病，包括癌症、眼部疾病、心脏疾病、肺部疾病、肾脏疾病、肝脏疾病和免疫功能障碍。因此，针对失调的 Hippo 成分的治疗策略可能是治疗广泛疾病的有前途的方法。在这里，我们回顾了 Hippo 通路的关键组成部分和上游信号，以及 Hippo 通路控制的关键生理功能。此外，还将讨论与 Hippo 通路改变相关的疾病和针对 Hippo 成分的潜在治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/4712c05095e0/41392_2022_1191_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/bd12aac41993/41392_2022_1191_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/5e6bda85c472/41392_2022_1191_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/a2593dba648a/41392_2022_1191_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/72c7bb675a79/41392_2022_1191_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/4712c05095e0/41392_2022_1191_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/bd12aac41993/41392_2022_1191_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/5e6bda85c472/41392_2022_1191_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/a2593dba648a/41392_2022_1191_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/72c7bb675a79/41392_2022_1191_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/9643504/4712c05095e0/41392_2022_1191_Fig5_HTML.jpg

相似文献

[1]
The Hippo signalling pathway and its implications in human health and diseases.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[10]
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[8]
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本文引用的文献

[1]
Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF-β Induced Osteogenic Target Genes.

Adv Biol (Weinh). 2021-2

[2]
Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers.

Cell Rep. 2022-8-30

[3]
Integrated screens uncover a cell surface tumor suppressor gene involved in Hippo pathway.

Proc Natl Acad Sci U S A. 2022-6-21

[4]
Apical-basal polarity and the control of epithelial form and function.

Nat Rev Mol Cell Biol. 2022-8

[5]
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy.

Mol Cell. 2022-5-19

[6]
Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis.

Acta Pharmacol Sin. 2022-11

[7]
LATS1 is a central signal transmitter for achieving full type-I interferon activity.

Sci Adv. 2022-4-8

[8]
IL-17A Promotes Psoriasis-Associated Keratinocyte Proliferation through ACT1-Dependent Activation of YAP-AREG Axis.

J Invest Dermatol. 2022-9

[9]
Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER breast cancer.

Nat Commun. 2022-2-25

[10]
Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites.

Nat Commun. 2022-2-17

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