Fleischmann A, Makman M H, Etgen A M
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461.
Brain Res. 1990 Jan 15;507(1):161-3. doi: 10.1016/0006-8993(90)90538-m.
In vivo treatment of ovariectomized rats with estradiol benzoate plus progesterone, but not with either steroid alone, produced a large increase in veratridine-induced release of radiolabeled glutamate and newly synthesized GABA from preoptic area synaptosomes in vitro. Neither basal nor KCl-evoked release of amino acids was altered. Thus gonadal steroids appear to be involved in the control of amino acid neurotransmitter release in a brain region of importance for regulation of female reproductive physiology and behavior.
