Ito Kimiteru, Kubota Kazuo, Morooka Miyako, Shida Yoshitaka, Hasuo Kanehiro, Endo Hisako, Matsuda Hiroshi
Department of Nuclear Medicine, Saitama Medical University International Medical Center, Hidaka, Saitama 350-1298, Japan.
Ann Nucl Med. 2009 Sep;23(7):671-6. doi: 10.1007/s12149-009-0292-y. Epub 2009 Aug 13.
The purpose of this study was to evaluate the usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in differentiating pulmonary artery sarcoma from pulmonary embolism.
We evaluated three patients with pulmonary artery sarcoma and 10 patients with proximal pulmonary embolism (6 men and 7 women, ranging in age from 35 to 94 years). All the patients had evidence of perfusion defects in their proximal pulmonary arteries on contrast-enhanced computed tomography (CT) scans performed prior to PET/CT. The maximum standardized uptake value (SUV(max)) of FDG uptake in all the lesions was measured using PET/CT. The location of lesions, background uptake or thrombi in the legs were evaluated in both groups as basic characteristics.
The mean SUV(max) of the pulmonary artery sarcomas (7.63 +/- 2.21, n = 3) and the pulmonary embolisms (2.31 +/- 0.41, n = 10) were significantly different (P < 0.05). The mean times between the initial contrast-enhanced CT scan and PET/CT scan were similar in both groups (P = 0.7804). The differences in the locations in lesions between the three groups (right, left and bilateral) or background uptakes were not significant.
FDG PET/CT could distinguish pulmonary artery sarcoma from pulmonary embolism based on the SUV(max) value.
本研究旨在评估18F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）在鉴别肺动脉肉瘤与肺栓塞方面的效用。
我们评估了3例肺动脉肉瘤患者和10例近端肺栓塞患者（6名男性和7名女性，年龄范围为35至94岁）。所有患者在PET/CT检查前进行的对比增强计算机断层扫描（CT）中均显示近端肺动脉存在灌注缺损。使用PET/CT测量所有病变中FDG摄取的最大标准化摄取值（SUV(max)）。评估两组病变的位置、腿部的背景摄取或血栓作为基本特征。
肺动脉肉瘤组（7.63±2.21，n = 3）和肺栓塞组（2.31±0.41，n = 10）的平均SUV(max)值有显著差异（P < 0.05）。两组初次对比增强CT扫描与PET/CT扫描之间的平均时间相似（P = 0.7804）。三组（右侧、左侧和双侧）病变位置或背景摄取的差异不显著。
FDG PET/CT可根据SUV(max)值区分肺动脉肉瘤与肺栓塞。
