Lehrstuhl für Lebensmittelchemie, Universität Würzburg, Würzburg D-97074, Germany.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Apr;26(4):563-7. doi: 10.1080/02652030802562920.
After simultaneous distillation-extraction (SDE) of foods packed in polystyrene (n = 77) and polypropylene cups (n = 42) from 61 different suppliers, coupled capillary gas chromatography-mass spectrometric (HRGC-MS) analyses indicated the presence of diastereomers of 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (TMPD-MIB; Texanol), a known coalescent of paints and printing inks. The contaminant was found in 55 and 50% of the polystyrene and polypropylene packed samples, respectively. Amounts ranged 1.2-64.5 microg kg(-1) in polystyrene cups (average 25.1 microg kg(-1)) and 0.9-45.7 microg kg(-1) in polypropylene cups (average 10.8 microg kg(-1)). The origin of Texanol in the printed plastic cups was demonstrated by separate HRGC-MS analysis, showing amounts in the higher microg kg(-1) range. In addition, the presence of two pairs of enantiomers, both found to be racemic by enantioselective multi-dimensional gas chromatography-mass spectrometry (enantio-MDGC-MS), excluded it being of natural origin. The detection limit of overall procedure (DLOP) and the reliable quantification limit (RQL) were 0.2 and 0.9 microg kg(-1), respectively. As the diester, 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB), is on the EU list of regulated substances (restricted to single-use gloves only) with a migration limit of 5 mg kg(-1) in food and is metabolised rapidly by hydrolysis, the observed migration of the monoester Texanol at the microg kg(-1) level poses no risk of adverse effects.
对 61 家不同供应商提供的聚苯乙烯（n = 77）和聚丙烯杯（n = 42）包装食品进行同步蒸馏萃取（SDE）后，结合毛细管气相色谱-质谱联用（HRGC-MS）分析表明，存在已知油漆和印刷油墨成膜剂的 2,2,4-三甲基-1,3-戊二醇二异丁酸酯（TMPD-MIB；Texanol）的非对映异构体。该污染物分别存在于 55%和 50%的聚苯乙烯和聚丙烯包装样品中。聚苯乙烯杯中的含量范围为 1.2-64.5 μg kg-1（平均值为 25.1 μg kg-1），聚丙烯杯中的含量范围为 0.9-45.7 μg kg-1（平均值为 10.8 μg kg-1）。通过单独的 HRGC-MS 分析证明了印刷塑料杯中的 Texanol 来源，显示出更高的μg kg-1 范围内的含量。此外，通过对映选择性多维气相色谱-质谱（enantio-MDGC-MS）分析发现存在两对对映异构体，均为外消旋，排除了其天然来源的可能性。整个过程的检测限（DLOP）和可靠定量限（RQL）分别为 0.2 和 0.9 μg kg-1。由于二酯 2,2,4-三甲基-1,3-戊二醇二异丁酸酯（TXIB）被列入欧盟受管制物质清单（仅限于一次性手套），其在食品中的迁移限量为 5 mg kg-1，且可迅速通过水解代谢，因此观察到的微毫克级 Texanol 单酯迁移不会对人体造成不利影响。
