Axe santé des populations et pratiques optimales en santé, Centre de recherche du CHU de Québec-Université Laval, 1050 Ch Ste-Foy, Quebec, QC, Canada.
Département de médecine sociale et préventive, Université Laval, 1030 Avenue de la Médecine, Quebec, QC, Canada.
J Expo Sci Environ Epidemiol. 2022 May;32(3):400-407. doi: 10.1038/s41370-022-00425-w. Epub 2022 Mar 28.
Persistent organic pollutant exposures are well-documented in the Arctic, but fewer studies examined non-persistent chemicals, despite increased market food and consumer product consumption.
To measure phenol, paraben, phthalate, and alternative plasticizer concentrations in Inuit adults.
The study included 30 pooled urine samples from Qanuilirpitaa? 2017 Nunavik Inuit Health Survey (Q2017) participants. Creatinine-adjusted geometric mean concentrations (GM) and 95% confidence intervals (CI) were compared across sex, age, and regions, and compared to those in the Canadian Health Measures Survey (CHMS) and the First Nations Biomonitoring Initiative (FNBI).
Q2017 bisphenol-A concentrations were double the CHMS 2018-2019 concentrations [GM (95% CI): 1.98 (1.69-2.31) versus 0.71 (0.60-0.84) µg/g creatinine], but in line with FNBI [1.74 (1.41-2.13) µg/g creatinine]. Several phthalate concentrations were higher in Q2017 versus CHMS, particularly monobenzyl phthalate, which was was 19-fold higher in Q2017 versus CHMS 2018-2019 [45.26 (39.35-52.06) versus 2.4 (2.0-2.9) µg/g creatinine] and four-fold higher than FNBI. There were also four-fold higher concentrations of the two alternate plasticizer 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TIXB) metabolites in Q2017 compared to CHMS 2018-2019. Women and people living in Ungava Bay had generally higher concentrations of non-persistent chemicals.
The results suggest higher concentrations of certain non-persistent chemicals in Inuit versus the general Canadian population.
Few studies have explored non-persistent chemical distributions in Northern communities, despite the increasing consumer product and market food consumption. We analyzed 30 pooled samples from the Qanuilirpitaa? Nunavik Inuit Health Survey 2017 to assess exposures to common plasticizes and plastic constituents and compare their levels with the general Canadian population and First Nation groups. We observed particularly higher levels of bisphenol-A, of monobenzyl phthalate, and of two 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB) metabolites among Nunavimmiut compared to the general Canadian population, notably among women and Ungava Bay residents. Larger studies are required to confirm our findings and identify potential adverse health effects from these exposures.
北极地区持久性有机污染物的暴露情况已有大量记录，但对非持久性化学物质的研究较少，尽管市场食品和消费产品的消费有所增加。
测量因纽特成年人尿液中的酚类、对羟基苯甲酸酯、邻苯二甲酸酯和替代增塑剂浓度。
该研究包括来自 2017 年努纳武特因纽特人健康调查（Q2017）的 30 个 pooled 尿液样本。按肌酐调整的几何均数浓度（GM）和 95%置信区间（CI）在性别、年龄和地区之间进行比较，并与加拿大健康测量调查（CHMS）和第一民族生物监测倡议（FNBI）进行比较。
Q2017 双酚 A 浓度是 CHMS 2018-2019 浓度的两倍[GM（95%CI）：1.98（1.69-2.31）与 0.71（0.60-0.84）µg/g 肌酐]，但与 FNBI 一致[1.74（1.41-2.13）µg/g 肌酐]。与 CHMS 相比，Q2017 中几种邻苯二甲酸酯浓度较高，特别是单苄基邻苯二甲酸酯，Q2017 中浓度是 CHMS 2018-2019 的 19 倍[45.26（39.35-52.06）与 2.4（2.0-2.9）µg/g 肌酐]，是 FNBI 的四倍。Q2017 中二异丁基对甲苯基邻苯二甲酸酯（TIXB）的两种替代增塑剂代谢物的浓度也高出四倍。与 CHMS 2018-2019 相比，Q2017 中女性和生活在 Ungava 湾的人的非持久性化学物质浓度通常更高。
结果表明，因纽特人的某些非持久性化学物质浓度高于加拿大一般人群。
尽管北方社区的消费产品和市场食品消费不断增加，但很少有研究探讨非持久性化学物质的分布情况。我们分析了来自 2017 年 Qanuilirpitaa？努纳武特因纽特人健康调查的 30 个 pooled 样本，以评估常见增塑剂和塑料成分的暴露情况，并将其水平与加拿大一般人群和第一民族群体进行比较。我们观察到，与加拿大一般人群相比，因纽特人尿液中的双酚 A、单苄基邻苯二甲酸酯和两种 2,2,4-三甲基-1,3-戊二醇二异丁酸酯（TXIB）代谢物的水平尤其较高，尤其是在女性和 Ungava 湾居民中。需要进行更大规模的研究来证实我们的发现，并确定这些暴露的潜在不良健康影响。
