Chemistry Division, Kanagawa Prefectural Institute of Public Health, Kanagawa, Japan.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Apr;26(4):568-73. doi: 10.1080/02652030802471221.
Abietic acid (AA) and dehydroabietic acid (DHA) have been detected in virgin paper products and recycled paper products used for food packaging. In order to evaluate the cell transformation activities of AA and DHA, the Bhas 42 cell-transformation assay for initiation and promotion was carried out. Tested in the initiation stage, AA and DHA did not significantly increase transformation frequencies. On the other hand, both chemicals induced transformed foci dose dependently at the promotion stage. The highest transformed foci density induced by AA was about 13 foci/well at 60 nmol ml(-1), and that of DHA was about 16 foci/well at 40 nmol ml(-1) (solvent control = 2.3 +/- 1.4 foci/well). The present results suggest that AA and DHA may have tumour-promoting potential.
松香酸（AA）和去氢松香酸（DHA）已在用于食品包装的原纸制品和再生纸制品中被检出。为了评估 AA 和 DHA 的细胞转化活性，进行了 Bhas 42 细胞转化试验，用于起始和促进阶段。在起始阶段进行测试时，AA 和 DHA 并未显著增加转化频率。另一方面，这两种化学物质在促进阶段均表现出剂量依赖性诱导转化灶。AA 诱导的最高转化灶密度约为 60 nmol ml(-1)时的 13 个灶/孔，DHA 诱导的最高转化灶密度约为 40 nmol ml(-1)时的 16 个灶/孔（溶剂对照为 2.3 +/- 1.4 个灶/孔）。目前的结果表明，AA 和 DHA 可能具有肿瘤促进潜力。
