Clarkson Cheryl, López Dolores E, Merchán Miguel A
Laboratorio de Neurobiología de la Audición, Facultad de Medicina, Universidad de Salamanca, Salamanca, Spain.
Acta Otolaryngol. 2010 Mar;130(3):326-32. doi: 10.1080/00016480903150536.
An intact bilateral auditory corticofugal projection is necessary for the auditory system, and above all its main targets, to start working correctly after an acoustic stimulation. After restricted unilateral cortical lesions, the auditory system is able to recover its function in adult animals at 90 days after surgery. (Post-lesion plasticity in adults.)
To study the influence of the cortex on the auditory system functionality and to asses its ability for post-lesion recovery.
Restricted unilateral lesions were made in the auditory cortex of adult rats. To evaluate the functionality of the auditory pathway after corticofugal deafferentation, the acoustic startle reflex and prepulse inhibition, together with the auditory brainstem response (ABR), were tested along the survival time.
All the three tests showed a decrease in their responses at 15 days post lesion, and a full recovery at 90 days post lesion for the ABR and at 180 days post lesion for the acoustic startle reflex and prepulse inhibition.
完整的双侧听觉皮质传出投射对于听觉系统，尤其是其主要靶区在声刺激后正常启动工作是必要的。在成年动物中，单侧皮质局限性损伤后，听觉系统在术后90天能够恢复其功能。（成年动物损伤后的可塑性。）
研究皮质对听觉系统功能的影响，并评估其损伤后恢复能力。
在成年大鼠听觉皮质制造单侧局限性损伤。为评估皮质传出神经切断后听觉通路的功能，在整个存活期测试了听觉惊跳反射、前脉冲抑制以及听觉脑干反应（ABR）。
所有这三项测试均显示，损伤后15天时反应降低，ABR在损伤后90天完全恢复，听觉惊跳反射和前脉冲抑制在损伤后180天完全恢复。
