Saito M, Gotoh M, Kato K, Kondo A
Department of Urology, Nagoya University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 1990 Jan;81(1):31-6. doi: 10.5980/jpnjurol1989.81.31.
To investigate the possible etiology of unstable bladder in the elderly, we investigated the responses of the aged rat bladder (16 and 24 months old) to 5 non-cholinergic, non-adrenergic neurotransmitters in comparison with the young rat bladder (6 months old). The drugs used were adenosine triphosphate, prostaglandin F2 alpha, serotonin, angiotensin II and vasoactive intestinal polypeptide. 1) The responses of 24-month-old rat bladders to adenosine triphosphate (ATP) were significantly greater than those of 6- and 16-month-old rats. 2) Prostaglandin F2 alpha made no difference in responses among three age groups. 3) The responses to serotonin of 24-month-old rat bladders were greater than those of the other two groups. 4) There was no difference in responses to angiotensin II in three age groups. 5) No response to vasoactive intestinal polypeptide was observed in all age groups. It is probable that the supersensitive responses to ATP and serotonin, observed in the aged rat bladders, may contribute to the development of unstable bladder in elderly people.
为了探究老年人膀胱不稳定的可能病因，我们研究了老年大鼠膀胱（16个月和24个月大）对5种非胆碱能、非肾上腺素能神经递质的反应，并与年轻大鼠膀胱（6个月大）进行比较。所使用的药物有三磷酸腺苷、前列腺素F2α、5-羟色胺、血管紧张素II和血管活性肠肽。1）24个月大的大鼠膀胱对三磷酸腺苷（ATP）的反应明显大于6个月和16个月大的大鼠。2）前列腺素F2α在三个年龄组的反应中没有差异。3）24个月大的大鼠膀胱对5-羟色胺的反应大于其他两组。4）三个年龄组对血管紧张素II的反应没有差异。5）在所有年龄组中均未观察到对血管活性肠肽的反应。老年大鼠膀胱中观察到的对ATP和5-羟色胺的超敏反应可能促成了老年人膀胱不稳定的发生。
