急性髓系白血病中的高催乳素血症及1例M4亚型患者原始细胞中人催乳素异位表达的指征

Hyperprolactinemia in acute myeloid leukemia and indication of ectopic expression of human prolactin in blast cells of a patient of subtype M4.

作者信息

Hatfill S J, Kirby R, Hanley M, Rybicki E, Böhm L

机构信息

Radiobiology Laboratory, Faculty of Medicine, University of Stellenbosch, Tygerberg, Republic of South Africa.

出版信息

Leuk Res. 1990;14(1):57-62. doi: 10.1016/0145-2126(90)90146-z.

DOI:10.1016/0145-2126(90)90146-z

PMID:1968111

Abstract

The sera of 28 patients with acute myeloid leukemia AML--subtypes M1 to M6 were screened for human prolactin (h-PRL). Serum TSH (thyroid stimulating hormone), LH (luteinizing hormone), FSH (follicle stimulating hormone), beta-estradiol, free T4 (tetra-iodotyronine) and testosterone were also determined. It was found that in 16 of the 28 patients h-PRL was significantly elevated while all other endocrine values were normal. In a patient subtype M4 with elevated serum h-PRL we demonstrate by immunoblotting that the hormone and its dimer are present in the blast cells. This may reflect ectopic synthesis due to altered expression of homeobox genes and a requirement of h-PRL as a growth stimulant of the leukemic myeloblast.

摘要

对28例急性髓系白血病（AML）-M1至M6亚型患者的血清进行人催乳素（h-PRL）筛查。同时测定血清促甲状腺激素（TSH）、黄体生成素（LH）、卵泡刺激素（FSH）、β-雌二醇、游离甲状腺素（T4）和睾酮。结果发现，28例患者中有16例h-PRL显著升高，而所有其他内分泌指标均正常。在1例血清h-PRL升高的M4亚型患者中，我们通过免疫印迹法证明原始细胞中存在该激素及其二聚体。这可能反映了由于同源框基因表达改变导致的异位合成，以及h-PRL作为白血病原始粒细胞生长刺激因子的需求。