Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, PR China.
Brain Res Bull. 2011 May 30;85(3-4):81-8. doi: 10.1016/j.brainresbull.2011.03.020. Epub 2011 Mar 30.
Given the tremendous success of deep brain stimulation (DBS) for the treatment of movement and neuropsychiatric disorders, clinicians have begun to open up to the possible use of electrical stimulation for the treatment of patients with uncontrolled seizures. DBS of various neural targets has been investigated in clinical studies and animal studies, including the anterior nucleus of thalamus (ANT), cerebellum, hippocampus, subthalamic nucleus (STN), centromedian nucleus of the thalamus (CMT), caudate nucleus (CN). Recently, a large and multicenter trial (SANTE: Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy) was conducted and subsequently with encouraging results, making ANT the most well-established target for DBS in the treatment of epilepsy to date. Here, we endeavor to review mainly the animal studies and clinical studies of ANT DBS to further explore the more reliable target.
鉴于深部脑刺激 (DBS) 在治疗运动和神经精神疾病方面取得了巨大成功，临床医生开始考虑将电刺激用于治疗癫痫发作无法控制的患者。临床研究和动物研究已经调查了各种神经靶点的 DBS，包括丘脑前核 (ANT)、小脑、海马体、丘脑底核 (STN)、丘脑中央中核 (CMT)、尾状核 (CN)。最近，一项大型多中心试验 (SANTE：丘脑前核刺激治疗癫痫) 进行了，并随后取得了令人鼓舞的结果，使 ANT 成为迄今为止治疗癫痫症 DBS 最成熟的靶点。在这里，我们主要努力回顾 ANT DBS 的动物研究和临床研究，以进一步探索更可靠的靶点。
