通过 NHC 催化的烯酮-酮环加成反应对映选择性合成β-三氟甲基-β-内酰胺。
Enantioselective synthesis of beta-trifluoromethyl-beta-lactones via NHC-catalyzed ketene-ketone cycloaddition reactions.
机构信息
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Org Lett. 2009 Sep 17;11(18):4029-31. doi: 10.1021/ol901290z.
PMID:19681591
Abstract
The highly diastereo- and enantioselective synthesis of beta-trifluoromethyl-beta-lactones bearing two contiguous stereocenters was realized by chiral N-heterocyclic carbene-catalyzed formal cycloaddition reaction of alkyl(aryl)ketenes and trifluoromethyl ketones.
摘要
通过手性 N-杂环卡宾催化的烷基（芳基）烯酮和三氟甲基酮的形式环加成反应，实现了具有两个相邻手性中心的β-三氟甲基-β-内酰胺的高非对映和对映选择性合成。
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