Division of Anesthesia and Intensive Care, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Acta Anaesthesiol Scand. 2009 Nov;53(10):1239-50. doi: 10.1111/j.1399-6576.2009.02064.x. Epub 2009 Aug 13.
The systemic physiologic changes that occur during and after brain death affect all organs suitable for transplantation. Major changes occur in the cardiovascular, pulmonary, endocrine, and immunological systems, and, if untreated may soon result in cardiovascular collapse and somatic death. Understanding these complex physiologic changes is mandatory for developing effective strategies for donor resuscitation and management in such a way that the functional integrity of potentially transplantable organs is maintained. This review elucidates these physiological changes and their consequences, and based on these consequences the rationale behind current medical management of brain-dead organ donors is discussed.
在脑死亡期间和之后发生的全身性生理变化会影响所有适合移植的器官。心血管、肺、内分泌和免疫系统会发生重大变化，如果不加以治疗，可能很快导致心血管衰竭和躯体死亡。了解这些复杂的生理变化对于制定有效的供体复苏和管理策略是必要的，以便维持潜在可移植器官的功能完整性。本综述阐明了这些生理变化及其后果，并根据这些后果讨论了目前脑死亡器官捐献者医学管理的基本原理。
