加速光诱导亲水性促进骨整合：一项动物研究。

Accelerated photo-induced hydrophilicity promotes osseointegration: an animal study.

机构信息

Division of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan.

出版信息

Clin Implant Dent Relat Res. 2011 Mar;13(1):79-85. doi: 10.1111/j.1708-8208.2009.00179.x.

DOI:10.1111/j.1708-8208.2009.00179.x

PMID:19681935

Abstract

BACKGROUND

In the previous in vitro study, fluoride-modified, anodized porous titanium was proven to have enhanced its photo-induced hydrophilicity, which induced the hyperactivation of initial cell response.

PURPOSE

The purpose of the present study was to investigate in vivo bone apposition during the early stages of osseointegration in rabbit tibiae.

MATERIALS AND METHODS

Anodized porous titanium implants (TiU, TiUnite®, Nobel Biocare AB, Göteborg, Sweden) were modified with 0.175 wt% ammonium hydrogen fluoride solution (NH(4) F-HF(2) ). Twenty-four hours prior to the experiments, the surface-modified implants were ultraviolet-irradiated (modTiU). Blinded and unpackaged TiU implants were used as controls. Thereafter, the implants were placed in the rabbit tibial metaphyses and histomorphometrically analyzed at 2 and 6 weeks after insertion.

RESULTS

ModTiU demonstrated a significantly greater degree of bone-to-metal contact than TiU after 2 and 6 weeks of healing.

CONCLUSION

The results proved that the enhanced photo-induced hydrophilicity of the NH(4) F-HF(2) -modified anodized implants promoted bone apposition during the early stages of osseointegration.

摘要

背景

在之前的体外研究中，证明了氟改性的阳极氧化多孔钛增强了其光诱导亲水性，从而诱导初始细胞反应的超激活。

目的

本研究旨在研究兔胫骨中早期骨整合过程中的骨附着。

材料和方法

用 0.175wt%的氟化铵氢氟酸溶液（NH 4 F-HF 2 ）对阳极氧化多孔钛植入物（TiU，TiUnite ®，Nobel Biocare AB，哥德堡，瑞典）进行改性。在实验前 24 小时，对表面改性的植入物进行紫外线照射（modTiU）。将盲包装和未包装的 TiU 植入物作为对照。然后，将植入物置于兔胫骨干骺端，并在植入后 2 和 6 周进行组织形态计量学分析。