Gittens Rolando A, Scheideler Lutz, Rupp Frank, Hyzy Sharon L, Geis-Gerstorfer Jürgen, Schwartz Zvi, Boyan Barbara D
Center for Biodiversity & Drug Discovery, Institute for Scientific Research and High Technology Services (INDICASAT-AIP), Panama, Panama.
Department of Prosthetic Dentistry, Section of Medical Materials and Technology, University Hospital Tübingen, Tübingen, Germany.
Acta Biomater. 2014 Jul;10(7):2907-18. doi: 10.1016/j.actbio.2014.03.032. Epub 2014 Apr 5.
Dental and orthopedic implants have been under continuous advancement to improve their interactions with bone and ensure a successful outcome for patients. Surface characteristics such as surface topography and surface chemistry can serve as design tools to enhance the biological response around the implant, with in vitro, in vivo and clinical studies confirming their effects. However, the comprehensive design of implants to promote early and long-term osseointegration requires a better understanding of the role of surface wettability and the mechanisms by which it affects the surrounding biological environment. This review provides a general overview of the available information about the contact angle values of experimental and of marketed implant surfaces, some of the techniques used to modify surface wettability of implants, and results from in vitro and clinical studies. We aim to expand the current understanding on the role of wettability of metallic implants at their interface with blood and the biological milieu, as well as with bacteria, and hard and soft tissues.
牙科和骨科植入物一直在不断发展，以改善它们与骨的相互作用，并确保患者获得成功的治疗效果。诸如表面形貌和表面化学等表面特性可作为设计工具，增强植入物周围的生物学反应，体外、体内和临床研究均证实了它们的作用。然而，为促进早期和长期骨整合而进行的植入物综合设计需要更好地理解表面润湿性的作用及其影响周围生物环境的机制。本综述概述了有关实验性和市售植入物表面接触角值的现有信息、一些用于改变植入物表面润湿性的技术，以及体外和临床研究的结果。我们旨在扩展目前对金属植入物在其与血液、生物环境以及细菌、硬组织和软组织界面处润湿性作用的理解。
