INSERM, U892, Centre de Recherche en Cancérologie Nantes-Angers, 44007 Nantes, France.
Immunol Lett. 2009 Dec 2;127(1):8-12. doi: 10.1016/j.imlet.2009.08.003. Epub 2009 Aug 12.
Recent studies suggest that gammadelta T cells are innate IL-17 producers owing to unique features of their developmental program. A key contribution of this subset to T helper 17 responses has been also suggested by numerous physiopathological studies mainly performed in mouse models. In the present review, we will summarize the main features of IL-17-producing gammadelta T cells and highlight the similarities and differences between murine gammadelta T cells and their human counterparts.
最近的研究表明，γδ T 细胞是先天的 IL-17 产生细胞，这归因于其发育程序的独特特征。大量主要在小鼠模型中进行的生理病理研究也提示了这一亚群对辅助性 T 细胞 17 反应的重要贡献。在本综述中，我们将总结产生 IL-17 的 γδ T 细胞的主要特征，并强调鼠类 γδ T 细胞与其人类对应物之间的相似性和差异性。
