强啡肽A-（1-13）的N，N-二烯丙基类似物作为内源性肽的强效拮抗剂和选择性κ阿片类镇痛药。 - Suppr | 超能文献

N,N-diallylated analogs of dynorphin A-(1-13) as potent antagonists for the endogenous peptide and selective kappa opioid analgesics.

作者信息

Lemaire S, Parent P, Lapierre C, Michelot R

机构信息

Department of Pharmacology, Faculty of Health Sciences, University of Ottawa, Ontario.

出版信息

Prog Clin Biol Res. 1990;328:45-8.

Abstract

摘要

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N,N-diallylated analogs of dynorphin A-(1-13) as potent antagonists for the endogenous peptide and selective kappa opioid analgesics.强啡肽A-（1-13）的N，N-二烯丙基类似物作为内源性肽的强效拮抗剂和选择性κ阿片类镇痛药。

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2

Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.小鼠输精管和豚鼠回肠中强啡肽选择性κ受体的比较。备用受体分数作为效力的决定因素。

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3

Dynorphin A(1-8): stability and implications for in vitro opioid activity.强啡肽A（1-8）：稳定性及其对体外阿片样物质活性的影响

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Evidence that dynorphin-(1-13) acts as an agonist on opioid kappa-receptors.强啡肽-（1-13）作为阿片κ受体激动剂的证据。

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[D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice.[D-脯氨酸10]-强啡肽(1-11)是小鼠中的一种κ选择性阿片类镇痛药。

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(-)-N,N'-but-2-ene-1,4-diylbimorphinans.（-）-N，N'-丁-2-烯-1,4-二基双吗啡喃类化合物。

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N,N-diallyl-tyrosyl substitution confers antagonist properties on the kappa-selective opioid peptide [D-Pro10]dynorphin A(1-11).N,N-二烯丙基-酪氨酰取代赋予κ-选择性阿片肽[D-脯氨酸10]强啡肽A（1-11）拮抗特性。

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E-2078, a potent, selective and stable dynorphin analog with preferential activity for the kappa-opioid receptor subtype on the mouse vas deferens neuroeffector junction.E-2078，一种强效、选择性且稳定的强啡肽类似物，对小鼠输精管神经效应器连接处的κ-阿片受体亚型具有优先活性。

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Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions.强啡肽A1-13通过阿片受体机制导致人体血清催乳素水平升高：性别差异及其在成瘾治疗中对多巴胺能张力调节的意义。

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Opioid-like properties of seven dynorphin (1-10) analogs.

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