Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.
J Autoimmun. 2009 Nov-Dec;33(3-4):165-9. doi: 10.1016/j.jaut.2009.07.007. Epub 2009 Aug 13.
This special edition of the Journal of Autoimmunity is dedicated to celebrate the enormous contributions of Dr. Noel Rose, a physician-scientist, someone that can be readily anointed as a gifted scientist who laid down the foundation and fundamental concepts of human autoimmunity. Dr. Rose performed a series of landmark studies that extend back more than 50 years and whose work is the cornerstone of the commonly used term "from the bench to the bedside." The studies included not only characterization of a normal immune response but, more importantly, defining the nature of not only the antigen, but also the aberrant response that results in organ, tissue specific reactions and immunopathology. These pioneering studies contributed to the biochemical nature of antigens, dissection of the immune repertoire, the recognition of the importance of genetics and environment, and the distinctions between a normal and an autoimmune response. Hence, this volume has been coined "Navigating the Passage Between Charybdis and Scylla: Recognizing the Achievements of Noel Rose."
本期《自身免疫杂志》特刊旨在向医学科学家、杰出科学家 Noel Rose 博士致敬，他为人类自身免疫奠定了基础并提出了基本概念。Rose 博士进行了一系列具有里程碑意义的研究，回溯时间超过 50 年，其工作是广泛使用的“从实验室到病床”这一术语的基石。这些研究不仅包括对正常免疫反应的特征描述，更重要的是，不仅定义了抗原的性质，还定义了导致器官、组织特异性反应和免疫病理学的异常反应的性质。这些开创性的研究有助于阐明抗原的生化性质、免疫库的剖析、认识遗传和环境的重要性，以及正常和自身免疫反应之间的区别。因此，本期特刊被命名为“在卡律布迪斯和斯库拉之间航行：认识 Noel Rose 的成就”。
