Hakamata Yuko, Iwase Mikio, Iwata Hiroshi, Kobayashi Toshiki, Tamaki Tsuneo, Nishio Masami, Matsuda Hiroshi, Ozaki Norio, Inada Toshiya
Department of Clinical Psychology, The University of Tokyo, Graduate School of Education, Tokyo, Japan.
Psychiatry Res. 2009 Sep 30;173(3):206-11. doi: 10.1016/j.pscychresns.2008.10.002. Epub 2009 Aug 13.
Recent functional neuroimaging studies have suggested that specific brain regions might be associated with the formation of anxiety-related personality traits, which are well known to be influenced by gender. Such anxiety-related personality traits are one of the representative predisposing factors for mood and anxiety disorders, whose incidence is also known to be much influenced by gender. However, little is known about the gender differences in brain function related to anxiety-related personality traits. The aim of the present study was to examine gender-related differences in the pattern of the relationships between an anxiety-related personality trait and cerebral brain glucose metabolism. Regional brain glucose metabolism was measured using [(18)F]fluorodeoxyglucose positron emission tomography in 102 healthy subjects (65 males and 37 females). An anxiety-related trait was assessed using the Temperament and Character Inventory dimension Harm Avoidance (HA). HA was negatively correlated with glucose metabolism in the anterior portion of the ventromedial prefrontal cortex (vmPFC) in females but not in males. The anterior vmPFC may be a possible neural target for the prevention or therapy of emotional disorders, especially in females.
最近的功能性神经影像学研究表明，特定脑区可能与焦虑相关人格特质的形成有关，而众所周知，这些特质会受到性别的影响。此类焦虑相关人格特质是情绪和焦虑障碍的代表性易感因素之一，其发病率也同样受到性别的显著影响。然而，关于与焦虑相关人格特质相关的脑功能性别差异，我们知之甚少。本研究的目的是探讨焦虑相关人格特质与脑葡萄糖代谢之间关系模式的性别差异。使用[（18）F]氟脱氧葡萄糖正电子发射断层扫描技术，对102名健康受试者（65名男性和37名女性）的脑区葡萄糖代谢进行了测量。使用气质与性格量表中的回避伤害维度（HA）来评估焦虑相关特质。在女性中，HA与腹内侧前额叶皮层（vmPFC）前部的葡萄糖代谢呈负相关，而在男性中则无此相关性。vmPFC前部可能是预防或治疗情绪障碍的一个潜在神经靶点，尤其是在女性中。
