Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy of the University Medical Center Göttingen, Göttingen, Germany.
Department of Clinical Neurophysiology of the University Medical Center Göttingen, Göttingen, Germany.
Sci Rep. 2019 Apr 4;9(1):5631. doi: 10.1038/s41598-019-42067-3.
High frequency repetitive transcranial magnetic stimulation (HF-rTMS) delivered to the left dorsolateral prefrontal cortex (DLPFC) is an effective treatment option for treatment resistant depression. However, the underlying mechanisms of a full session of HF-rTMS in healthy volunteers have not yet been described. Here we investigated, with a personalized selection of DLPFC stimulation sites, the effects driven by HF-rTMS in healthy volunteers (n = 23) over the default mode network (DMN) in multiple time windows. After a complete 10 Hz rTMS (3000 pulses) session, we observe a decrease of functional connectivity between the DMN and the subgenual Anterior Cingulate Cortex (sgACC), as well as the ventral striatum (vStr). A negative correlation between the magnitude of this decrease in the right sgACC and the harm avoidance domain measure from the Temperament and Character Inventory was observed. Moreover, we identify that coupling strength of right vStr with the DMN post-stimulation was proportional to a decrease in self-reports of negative mood from the Positive and Negative Affect Schedule. This shows HF-rTMS attenuates perception of negative mood in healthy recipients in agreement with the expected effects in patients. Our study, by using a personalized selection of DLPFC stimulation sites, contributes understanding the effects of a full session of rTMS approved for clinical use in depression over related brain regions in healthy volunteers.
高频重复经颅磁刺激（HF-rTMS）作用于左侧背外侧前额叶皮层（DLPFC）是治疗难治性抑郁症的有效治疗选择。然而，健康志愿者接受一整套 HF-rTMS 的潜在机制尚未描述。在这里，我们通过个性化选择 DLPFC 刺激部位，研究了 HF-rTMS 在健康志愿者（n=23）中对默认模式网络（DMN）的影响，在多个时间窗口中。在完整的 10 Hz rTMS（3000 个脉冲）疗程后，我们观察到 DMN 与前扣带皮层（sgACC）和腹侧纹状体（vStr）之间的功能连接减少。右侧 sgACC 中这种减少的幅度与气质和性格量表中的回避倾向度量之间存在负相关。此外，我们发现右侧 vStr 与 DMN 刺激后的耦合强度与积极和消极情绪量表中自我报告的负面情绪减少成正比。这表明 HF-rTMS 可减轻健康受者对负面情绪的感知，这与预期在患者中的治疗效果一致。我们的研究通过个性化选择 DLPFC 刺激部位，有助于理解已批准用于抑郁症临床治疗的一整套 rTMS 对健康志愿者相关脑区的影响。
