Elsabee Maher Z, Morsi Rania Elsayed, Al-Sabagh A M
Department of Chemistry, Faculty of Science, Cairo University, 12613 Cairo 12613, Egypt.
Colloids Surf B Biointerfaces. 2009 Nov 1;74(1):1-16. doi: 10.1016/j.colsurfb.2009.06.021. Epub 2009 Jun 23.
This review discusses the definition of surface active agents and specifically natural polymeric surface active agents. Chitosan by itself was found to have weak surface activity since it has no hydrophobic segments. Chemical modifications of chitosan could improve such surface activity. This is achieved by introducing hydrophobic substituents in its glucosidic group. Several examples of chitosan derivatives with surfactant activity have been surveyed. The surface active polymers form micelles and aggregates which have enormous importance in the entrapment of water-insoluble drugs and consequently applications in the controlled drug delivery and many biomedical fields. Chitosan also interacts with several substrates by electrostatic and hydrophobic interactions with considerable biomedical applications.
本综述讨论了表面活性剂的定义，特别是天然高分子表面活性剂。发现壳聚糖本身具有较弱的表面活性，因为它没有疏水链段。壳聚糖的化学修饰可以改善这种表面活性。这是通过在其糖苷基团中引入疏水取代基来实现的。已经研究了几种具有表面活性剂活性的壳聚糖衍生物的例子。表面活性聚合物形成胶束和聚集体，这在包封水不溶性药物以及因此在控释药物递送和许多生物医学领域的应用中具有极其重要的意义。壳聚糖还通过静电和疏水相互作用与几种底物相互作用，具有相当多的生物医学应用。
