University of Ljubljana, Biotechnical Faculty, Department of Biology, Vecna pot 111, SI-1000 Ljubljana, Slovenia.
Toxicology. 2010 Mar 10;269(2-3):198-203. doi: 10.1016/j.tox.2009.08.004. Epub 2009 Aug 13.
A number of reports on potential toxicity of nanoparticles are available, but there is still a lack of knowledge concerning bioaccumulation. The aim of this work was to investigate how different sources of zinc, such as uncoated and unmodified ZnO nanoparticles, ZnCl(2) in solution, and macropowder ZnO influence the bioaccumulation of this metal in the terrestrial isopod Porcellio scaber. After exposure to different sources of Zn in the diet, the amount of assimilated Zn in whole body, the efficiency of zinc assimilation, and bioaccumulation factors (BAFs) were assessed. The bioaccumulation potential of Zn was found to be the same regardless of Zn source. The amount of assimilated Zn and BAF were dose-dependent, and Zn assimilation efficiency was independent of exposure concentrations. The Zn assimilation capacity was found to be up to 16% of ingested Zn. It is known that as much as approximately 20% of Zn can be accreted from ZnO particles by dissolution. We conclude that bioaccumulation of Zn in isopods exposed to particulate ZnO depends most probably on Zn dissolution from ZnO particles and not on bioaccumulation of particulate ZnO.
目前已有大量关于纳米粒子潜在毒性的报告，但关于生物累积的知识仍然缺乏。本研究的目的是探讨不同锌源（如未涂层和未经修饰的 ZnO 纳米粒子、溶液中的 ZnCl2 以及大尺寸 ZnO 粉末）如何影响陆生等足目动物 Porcellio scaber 对这种金属的生物累积。在饮食中接触不同来源的 Zn 后，评估了整个生物体中同化的 Zn 量、Zn 同化效率和生物累积因子 (BAF)。发现 Zn 的生物累积潜力与 Zn 来源无关。同化的 Zn 量和 BAF 与暴露浓度呈剂量依赖性，而 Zn 同化效率与暴露浓度无关。Zn 的同化能力高达摄入 Zn 的 16%。已知约 20%的 Zn 可以通过溶解从 ZnO 颗粒中吸收。我们得出结论，暴露于颗粒状 ZnO 的等足目动物体内 Zn 的生物累积很可能主要取决于 ZnO 颗粒的 Zn 溶解，而不是颗粒状 ZnO 的生物累积。
