Allison Ron R, Zervos Emmanuel, Sibata Claudio H
Radiation Oncology Department, PDT Center, Brody School of Medicine, Greenville, NC 27834-4300, USA.
Photodiagnosis Photodyn Ther. 2009 Jun;6(2):84-92. doi: 10.1016/j.pdpdt.2009.05.001. Epub 2009 Jun 7.
Cholangiocarcinoma (CC) is emerging as an important treatment indication for photodynamic therapy. CCs are generally unresectable locally invasive tumors that occlude the biliary tree leading to fatal cholangitis and liver failure. Biliary decompression via stenting offers symptomatic relief but does not control tumor growth. Founded on an initial case study followed by ever more sophisticated clinical research, including randomized trials, photodynamic therapy has garnered enough momentum to be considered as part of the standard of care for these patients. Further, preliminary clinical data show the potential for benefit of the use of PDT in a neoadjuvant and adjuvant fashion to the minority of patients currently considered resectable or of border line resectability. PDT also impacts interleukin-6 levels and may form the basis for a targeted therapy approach to this disease. We review the clinical rationale, current studies and potential future directions of PDT for patients with CC.
胆管癌（CC）正逐渐成为光动力疗法的一个重要治疗指征。胆管癌通常是局部浸润性肿瘤，无法切除，会阻塞胆管树，导致致命的胆管炎和肝衰竭。通过支架置入进行胆道减压可缓解症状，但无法控制肿瘤生长。基于最初的病例研究以及越来越复杂的临床研究（包括随机试验），光动力疗法已获得足够的发展动力，被视为这些患者标准治疗的一部分。此外，初步临床数据显示，对于目前被认为可切除或处于临界可切除状态的少数患者，以新辅助和辅助方式使用光动力疗法有潜在益处。光动力疗法还会影响白细胞介素-6水平，可能构成针对该疾病的靶向治疗方法的基础。我们综述了光动力疗法治疗胆管癌患者的临床理论依据、当前研究及潜在的未来发展方向。
