Parsons J Kellogg, Im Ronald
Department of Surgery, Division of Urologic Oncology, Moores Comprehensive Cancer Center, University of California San Diego and VA Medical Center San Diego, La Jolla, California 92103-8897, USA.
J Urol. 2009 Oct;182(4):1463-8. doi: 10.1016/j.juro.2009.06.038. Epub 2009 Aug 15.
While some studies have indicated that alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia, others have not. We evaluated associations of alcohol consumption with benign prostatic hyperplasia and male lower urinary tract symptoms.
We performed a meta-analysis of published studies pertaining to alcohol intake, benign prostatic hyperplasia and lower urinary tract symptoms. We analyzed abstracted data with random effects models to obtain pooled odds ratios of adjusted effects estimates.
A total of 19 studies (120,091 men) met selection criteria and of these studies 14 revealed a significantly decreased likelihood of benign prostatic hyperplasia or lower urinary tract symptoms with increased alcohol intake. Sixteen studies were eligible for pooled analyses, of which 12 used benign prostatic hyperplasia as the primary outcome. We stratified total alcohol intake by gm per day into 6 strata. Alcohol intake was associated with a significantly or marginally significantly decreased likelihood of benign prostatic hyperplasia in all 6 strata (p values 0.08, 0.01, <0.001, 0.02, 0.001 and <0.001, respectively). Compared to no alcohol intake, an alcohol intake of 36 gm daily or greater was associated with a 35% decreased likelihood of benign prostatic hyperplasia (OR 0.65, 95% CI 0.58-0.74, p <0.001). Of the 4 studies that used lower urinary tract symptoms as the primary outcome 3 demonstrated a significantly increased likelihood of lower urinary tract symptoms with alcohol consumption.
Alcohol consumption is associated with a decreased likelihood of benign prostatic hyperplasia but not of lower urinary tract symptoms. Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia.
虽然一些研究表明饮酒与良性前列腺增生风险降低有关，但其他研究则未发现此关联。我们评估了饮酒与良性前列腺增生及男性下尿路症状之间的关联。
我们对已发表的有关酒精摄入、良性前列腺增生和下尿路症状的研究进行了荟萃分析。我们使用随机效应模型分析提取的数据，以获得调整效应估计值的合并比值比。
共有19项研究（120,091名男性）符合入选标准，其中14项研究显示，随着酒精摄入量增加，良性前列腺增生或下尿路症状的可能性显著降低。16项研究符合汇总分析条件，其中12项以良性前列腺增生作为主要结局。我们将每日酒精总摄入量按克分层为6个层次。在所有6个层次中，酒精摄入与良性前列腺增生的可能性显著或略微显著降低相关（p值分别为0.08、0.01、<0.001、0.02、0.001和<0.001）。与不饮酒相比，每日酒精摄入量为36克或更多与良性前列腺增生的可能性降低35%相关（比值比0.65，95%置信区间0.58 - 0.74，p <0.001）。在以尿路症状作为主要结局的4项研究中，3项显示饮酒会使尿路症状的可能性显著增加。
饮酒与良性前列腺增生可能性降低有关，但与下尿路症状无关。需要进一步研究以确定酒精改变良性前列腺增生风险的机制。
