新型两亲性聚乳酸-超支化聚甘油缀合物的合成及理化性质表征及其用于蛋白质递送。
Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein delivery.
机构信息
Key Laboratory of Functional Polymer Materials of Ministry Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.
出版信息
J Control Release. 2009 Dec 3;140(2):141-7. doi: 10.1016/j.jconrel.2009.08.003. Epub 2009 Aug 13.
Amphiphilic copolymers with polylactic acid (PLA) chains grafted onto hyperbranched polyglycerol (HPG) have been synthesized and characterized. The copolymer nanoparticles with corona and core structure were formed by self-assembly in aqueous solution. The loading capacity and association efficiency were up to 23% and 86%, respectively. Protein release profiles with different copolymer compositions and BSA concentrations all showed a burst effect followed by a continuous release phase. The released BSA from the copolymer nanoparticles remained in its original structure over a period of 4 days, as testified by circular dichroism spectroscopy. Furthermore, cell viability research suggested good biocompatibility of the copolymer nanoparticles, which have a promising potential for protein delivery system.
具有接枝到支化聚甘油（HPG）上的聚乳酸（PLA）链的两亲性共聚物已被合成并进行了表征。该共聚物在水溶液中通过自组装形成具有冠和核结构的胶束。载药量和结合效率分别高达 23%和 86%。具有不同共聚物组成和 BSA 浓度的蛋白质释放曲线均显示出突释效应，随后是持续释放阶段。圆二色光谱证明，共聚物胶束中释放的 BSA 在 4 天内保持其原始结构。此外，细胞活力研究表明共聚物胶束具有良好的生物相容性，有望成为蛋白质递送系统。
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