早发型而非晚发型子痫前期中氧化应激增加以及纤溶酶原激活物抑制剂（PAI）-1与PAI-2比例变化的证据。
Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia.
作者信息
Wikström Anna-Karin, Nash Peppi, Eriksson Ulf J, Olovsson Matts H
机构信息
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
出版信息
Am J Obstet Gynecol. 2009 Dec;201(6):597.e1-8. doi: 10.1016/j.ajog.2009.06.024. Epub 2009 Aug 15.
OBJECTIVE
The aims of this study were to measure the degree of oxidative stress and alterations in plasminogen activator inhibitor (PAI) type 1 and PAI-2 ratio in women with early-onset and late-onset preeclampsia.
STUDY DESIGN
A case-control study was conducted in women with early-onset (24-32 weeks' gestation; n=18) and late-onset (35-42 weeks' gestation; n=20) preeclampsia and in control pregnant women at corresponding gestational weeks. Placenta, urine, and serum samples were collected.
RESULTS
In early-onset preeclampsia, the median placental concentration of 8-iso-prostaglandin (PG)-F2alpha was higher and the PAI-1 to PAI-2 ratio higher than in early controls. These values did not differ between women with late-onset preeclampsia and their corresponding controls. Serum concentrations of 8-iso-PGF2alpha and vitamins C and E did not differ between cases and controls.
CONCLUSION
Early-onset but not late-onset preeclampsia is associated with increased placental oxidative stress and increased PAI-1 to PAI-2 ratio.
目的
本研究旨在测定早发型和晚发型子痫前期女性的氧化应激程度以及纤溶酶原激活物抑制剂（PAI）-1和PAI-2比例的变化。
研究设计
对早发型（妊娠24 - 32周；n = 18）和晚发型（妊娠35 - 42周；n = 20）子痫前期女性以及相应孕周的对照孕妇进行了一项病例对照研究。收集了胎盘、尿液和血清样本。
结果
在早发型子痫前期中，8 - 异前列腺素（PG）-F2α的胎盘浓度中位数高于早期对照组，PAI - 1与PAI - 2的比例也更高。晚发型子痫前期女性与其相应对照组之间这些值没有差异。病例组和对照组之间血清8 - 异前列腺素F2α以及维生素C和E的浓度没有差异。
结论
早发型而非晚发型子痫前期与胎盘氧化应激增加以及PAI - 1与PAI - 2比例增加有关。
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