Maesen F P, Smeets J J, Gubbelmans H L, Zweers P G
Department of Pulmonary Diseases, De Wever Hospital, Heerlen, The Netherlands.
Chest. 1990 Mar;97(3):590-4. doi: 10.1378/chest.97.3.590.
The bronchodilator effects were compared in 16 stable asthma patients for 12 hours after either 12 micrograms formoterol or 200 micrograms salbutamol from a metered-dose aerosol in a randomized, double-blind, crossover study. The FEV1 measured before 1, 2, 4, 6, 8, 10 and 12 hours after administration was used as the parameter. From 2 hours onwards after dosage, the bronchodilator effect of formoterol was statistically significantly greater than that of salbutamol. The effect of formoterol lasted longer, and even after 12 hours, the FEV1 was still 20 percent above the baseline value. This is clinically significant and offers new possibilities for treatment of the so-called "morning dip." Both agents were well tolerated.
在一项随机、双盲、交叉研究中，对16名稳定期哮喘患者使用定量气雾剂分别吸入12微克福莫特罗或200微克沙丁胺醇后12小时内的支气管扩张作用进行了比较。将给药前及给药后1、2、4、6、8、10和12小时测得的第一秒用力呼气容积（FEV1）作为参数。给药后2小时起，福莫特罗的支气管扩张作用在统计学上显著强于沙丁胺醇。福莫特罗的作用持续时间更长，甚至在12小时后，FEV1仍比基线值高出20%。这具有临床意义，并为治疗所谓的“晨降”提供了新的可能性。两种药物耐受性均良好。
