Maciel Elinês O, Carvalhal Gustavo F, da Silva Vinícius D, Batista Eraldo L, Garicochea Bernardo
Department of Pediatric Surgery, Pontifícia Universidade Católica, Porto Alegre, Brazil.
J Urol. 2009 Oct;182(4):1594-9. doi: 10.1016/j.juro.2009.06.011. Epub 2009 Aug 15.
There is potential interaction between malignant cell growth and the coagulation pathway. Recent studies suggest that tissue factor, a primary initiator of the extrinsic coagulation pathway, is expressed in various solid tumors in association with increased angiogenesis. To our knowledge we report for the first time the detection of tissue factor expression by immunohistochemistry in Wilms tumors and its correlation with clinical outcomes.
Tissue factor expression detected by immunohistochemistry was assessed in 41 formalin fixed, paraffin embedded Wilms tumor cases treated at university hospitals. We correlated findings with tumor recurrence and cancer specific survival.
Positive immunohistochemistry detection of tissue factor was observed in 88.3% of the tumors analyzed. Tissue factor on immunohistochemistry was associated with tumor recurrence and survival (p = 0.01 and 0.02, respectively). Increased immunohistochemical detection of tissue factor was the most important risk factor for recurrence and mortality in our population on bivariate and multivariate analysis.
Tissue factor is a promising research subject as a prognostic factor for Wilms tumor. More studies are needed to clarify the mechanisms by which tissue factor affects cancer progression and outcome, and its potential role as a therapeutic target.
恶性细胞生长与凝血途径之间可能存在相互作用。近期研究表明，组织因子作为外源性凝血途径的主要启动因子，在各种实体瘤中表达，并与血管生成增加相关。据我们所知，我们首次报告了通过免疫组织化学检测肾母细胞瘤中组织因子的表达及其与临床结局的相关性。
在大学医院治疗的41例福尔马林固定、石蜡包埋的肾母细胞瘤病例中，评估通过免疫组织化学检测的组织因子表达。我们将研究结果与肿瘤复发和癌症特异性生存情况相关联。
在分析的88.3%的肿瘤中观察到组织因子的免疫组织化学阳性检测。免疫组织化学检测的组织因子与肿瘤复发和生存相关（分别为p = 0.01和0.02）。在单变量和多变量分析中，免疫组织化学检测到的组织因子增加是我们研究人群中复发和死亡的最重要危险因素。
组织因子作为肾母细胞瘤的预后因素是一个有前景的研究课题。需要更多研究来阐明组织因子影响癌症进展和结局的机制，以及其作为治疗靶点的潜在作用。
