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1
Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.刺猬信号通路的变异：Sufu对Gli调控中的分歧与延续
Genes Dev. 2009 Aug 15;23(16):1843-8. doi: 10.1101/gad.1838109.
2
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.在刺猬信号通路中，Sufu对Gli蛋白功能的非纤毛依赖性调控在进化上是保守的。
Genes Dev. 2009 Aug 15;23(16):1910-28. doi: 10.1101/gad.1794109.
3
Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling.Daz 相互作用蛋白 1（Dzip1）稳定斑型 POZ 蛋白（Spop）对于 Gli 周转和 Hedgehog 信号的适当输出是必需的。
J Biol Chem. 2013 Nov 8;288(45):32809-32820. doi: 10.1074/jbc.M113.512962. Epub 2013 Sep 26.
4
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.融合抑制因子和 Spop 调节 Gli2 和 Gli3 全长激活物的稳定性、加工和功能，但不调节它们的抑制物。
Development. 2010 Jun;137(12):2001-9. doi: 10.1242/dev.052126. Epub 2010 May 12.
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Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.Spop在小鼠脊髓背腹模式形成中调节Gli3活性和Shh信号通路。
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Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.通过 DYRK2 激酶对 GLI2/GLI3 的磷酸化正向调控 Hedgehog 信号通路。
Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2320070121. doi: 10.1073/pnas.2320070121. Epub 2024 Jul 5.
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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.Hedgehog 信号的输出受融合抑制因子（Suppressor of Fused）与 Gli 蛋白之间动态结合的控制。
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Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.蛋白激酶 A 在初级纤毛的基体处发挥作用，以防止 Gli2 的激活和小鼠神经管的腹侧化。
Development. 2011 Nov;138(22):4921-30. doi: 10.1242/dev.070805. Epub 2011 Oct 17.
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Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling.Spop通过正向调节Ihh信号通路来促进骨骼发育和稳态。
Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14751-14756. doi: 10.1073/pnas.1612520114. Epub 2016 Dec 5.

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Primary Ciliary Signaling in the Skin-Contribution to Wound Healing and Scarring.皮肤中的初级纤毛信号传导——对伤口愈合和瘢痕形成的作用
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Role of Sonic Hedgehog Signaling Pathway in Intervertebral Disc Formation and Maintenance.音猬因子信号通路在椎间盘形成与维持中的作用
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Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma. hedgehog 信号通路在骨肉瘤发生发展和转移中的作用及其在骨肉瘤临床治疗中的潜在价值。
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Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway.融合抑制因子调控刺猬信号通路的分子机制
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Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin.通过Gli3/Fgfs/ Gremlin确定指（趾）数量和身份需要融合抑制因子。
PLoS One. 2015 May 22;10(5):e0128006. doi: 10.1371/journal.pone.0128006. eCollection 2015.
8
A novel PEGylated liposome-encapsulated SANT75 suppresses tumor growth through inhibiting hedgehog signaling pathway.一种新型聚乙二醇化脂质体包裹的 SANT75 通过抑制 hedgehog 信号通路抑制肿瘤生长。
PLoS One. 2013;8(4):e60266. doi: 10.1371/journal.pone.0060266. Epub 2013 Apr 1.
9
Loss of SUFU function in familial multiple meningioma.家族性多发性脑膜瘤中 SUFU 功能丧失。
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10
Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation.果蝇中 Costal 2 和 PKA 对哺乳动物 Gli 蛋白的调控揭示了 Hedgehog 信号通路的保守性。
Development. 2011 Jun;138(12):2533-42. doi: 10.1242/dev.063479.

本文引用的文献

1
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.在刺猬信号通路中，Sufu对Gli蛋白功能的非纤毛依赖性调控在进化上是保守的。
Genes Dev. 2009 Aug 15;23(16):1910-28. doi: 10.1101/gad.1794109.
2
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.哺乳动物 Cos2 同源物 Kif7 在发育过程中调节 Hh 信号转导中发挥重要作用。
Curr Biol. 2009 Aug 11;19(15):1320-6. doi: 10.1016/j.cub.2009.06.046. Epub 2009 Jul 9.
3
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.驱动蛋白Kif7是哺乳动物刺猬信号通路中Gli转录因子的关键调节因子。
Sci Signal. 2009 Jun 23;2(76):ra29. doi: 10.1126/scisignal.2000405.
4
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia.在没有纤毛的情况下，融合抑制因子抑制哺乳动物的刺猬信号通路。
Dev Biol. 2009 Jun 15;330(2):452-60. doi: 10.1016/j.ydbio.2009.04.009. Epub 2009 Apr 14.
5
Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.Fused在脊椎动物刺猬信号通路和运动性纤毛发生中发挥了不同的作用。
Nature. 2009 May 7;459(7243):98-102. doi: 10.1038/nature07883. Epub 2009 Mar 22.
6
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.由Smoothened介导的刺猬信号转导：两步激活过程的药理学证据
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3196-201. doi: 10.1073/pnas.0813373106. Epub 2009 Feb 13.
7
Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.激酶组siRNA筛选鉴定出纤毛发生和刺猬信号转导的调节因子。
Sci Signal. 2008 Sep 30;1(39):ra7. doi: 10.1126/scisignal.1162925.
8
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling.活性和激酶缺陷型激酶组文库在鉴定调控刺猬信号通路的激酶中的应用。
Cell. 2008 May 2;133(3):537-48. doi: 10.1016/j.cell.2008.02.047.
9
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation.通过Ci磷酸化对Ci-SCFSlimb结合、Ci蛋白水解和刺猬信号通路活性的调控。
Dev Cell. 2007 Oct;13(4):481-95. doi: 10.1016/j.devcel.2007.09.006.
10
Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.激酶Fused对非典型驱动蛋白Costal2的磷酸化作用可诱导Hedgehog信号通路中Smoothened-Fused-Costal2-Cubitus interruptus复合物的部分解体。
Development. 2007 Oct;134(20):3677-89. doi: 10.1242/dev.011577. Epub 2007 Sep 19.

刺猬信号通路的变异：Sufu对Gli调控中的分歧与延续

Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.

作者信息

Ruel Laurent, Thérond Pascal P

机构信息

Institut Biologie du Développement et Cancer-IBDC, Université de Nice-Sophia Antipolis, CNRS UMR 6543, Centre de Biochimie, Nice Cedex 02, France.

出版信息

Genes Dev. 2009 Aug 15;23(16):1843-8. doi: 10.1101/gad.1838109.

DOI:10.1101/gad.1838109
PMID:19684109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2725945/
Abstract

The Hedgehog (Hh) proteins play a universal role in metazoan development. Nevertheless, fundamental differences exist between Drosophila and vertebrates in the transduction of the Hh signal, notably regarding the role of primary cilia in mammalian cells. In this issue of Genes & Development, Chen and colleagues (pp. 1910-1928) demonstrate that mouse Suppressor of fused (Sufu) regulates the stability of the transcription factors Gli2 and Gli3 by antagonizing the conserved Gli degradation device mediated by Hib/Spop in a cilia-independent manner.

摘要

刺猬（Hh）蛋白在多细胞动物发育中发挥着普遍作用。然而，果蝇和脊椎动物在Hh信号转导方面存在根本差异，特别是在初级纤毛在哺乳动物细胞中的作用方面。在本期《基因与发育》中，陈及其同事（第1910 - 1928页）证明，小鼠融合抑制因子（Sufu）通过以不依赖纤毛的方式拮抗由Hib/Spop介导的保守Gli降解机制，来调节转录因子Gli2和Gli3的稳定性。