Institute of Medical and Biological Engineering, Medical Research Center, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Blood Purif. 2009;28(3):260-7. doi: 10.1159/000232934. Epub 2009 Aug 14.
BACKGROUND/AIMS: Blood flow profiles in fiber bundles depend on the design of the arterial port and affects the biocompatibility of the hemodialyzer. We analyzed the effects of arterial port design on blood flow distribution in fiber bundles using nonintrusive imaging techniques.
The velocity fields in arterial ports and the hemodynamics in fiber bundles were analyzed for hemodialyzers with different configurations using particle image velocimetry and perfusion computed tomography.
In a hemodialyzer with standard arterial ports, high blood flow profiles in the central and peripheral regions and low blood profiles in the middle region were developed due to jet flow and vortices around the jet. In a hemodialyzer with spiral arterial ports, higher flow profiles were developed due to the central vortices that decrease perfusion into the fiber bundles.
The arterial port design of hemodialyzers should be optimized such that jet flow and vortices do not impair dialysis efficiency and biocompatibility.
背景/目的：纤维束中的血流分布取决于动脉端口的设计，这会影响血液透析器的生物相容性。我们使用非侵入性成像技术分析了动脉端口设计对纤维束中血流分布的影响。
使用粒子图像测速法和灌注计算机断层扫描法分析了具有不同结构的血液透析器中动脉端口的速度场和纤维束中的血液动力学。
在具有标准动脉端口的血液透析器中，由于射流和射流周围的涡流，在中心和外围区域形成了高血流分布，而在中间区域形成了低血流分布。在具有螺旋动脉端口的血液透析器中，由于中央涡流会降低纤维束中的灌注，因此形成了更高的血流分布。
血液透析器的动脉端口设计应进行优化，以避免射流和涡流降低透析效率和生物相容性。
